Owing to the polarity characteristics of monoterpene glycosides, a centrifugal partition chromatography (CPC) technique played a critical role in the separation workflow. rosea monoterpenoids in order to potentially offer new aspects in botanical adaptogen research. Thus, it was considered of interest to explore the structural diversity of R. rosea can be considered underexplored, especially as the monoterpenoids occurring in this species likely play a role in the adaptogenic effect. 5 However, from a bioactivity and mechanism-of action as well as from a chemodiversity perspective, R. 5 Moreover, a monoterpene glycoside, rosiridin, obtained from the extract by bioassay-guided isolation showed the highest activity among the isolates. rosea showed a potentially beneficial effect associated with depression and senile dementia. rosea, they have not been studied systematically, and only a few investigations have described the bioactivity of Rhodiola monoterpenes. While monoterpenes are widely distributed in R. However, documented pharmacological and mechanistic studies mainly focus on Rhodiola extract, salidroside (a phenylethanoid) and the rosavins (phenylpropanoids) as its major constituents. 4Ī comprehensive literature survey revealed that the major constituents in this plant are proanthocyanidins, phenylpropanoids, phenylethanoids, flavonoids, monoterpenoids, and cyanogenic glycosides.

rosea prolonged endurance in a number of animal studies, as well as clinical evaluations that showed a clear stimulating effect on mental activity and on the magnitude and intensity of mechanical work, particularly against a background of fatigue. rosea as a tonic in Siberian and Russian medicine stimulated extensive research leading to early experimental research revealing that R. rosea have been used in folk medicine in the western Siberia Region of Russia, particularly in the Altai region, as means of relieving fatigue and increasing energy, especially during extended periods of strenuous activity. 1– 3 The adaptogenic or resilience-enhancing activities of this plant are purported to increase the body’s nonspecific resistance, reduce stress-induced impairments, and ameliorate disorders to neuro-endocrine and immune systems. (commonly known as roseroot, rose root, or goldenroot) in the family Crassulaceae has emerged as a popular botanical dietary supplement exhibiting adaptogenic effects in situations of decreased performance such as fatigue and sensation of weakness.

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